“[scientists] are seemingly no nearer to a grand theory of everything than we were when we first embarked upon this quest.”

Your comment is echoed in the last words of Isaac Newton, who was perhaps the most significant “proto” scientist: “I don’t know what I may seem to the world. But as to myself I seem to have been only like a boy playing on the seashore and diverting myself now and then finding a smoother pebble or a prettier shell than the ordinary, whilst the great ocean of truth lay all undiscovered before me.”

But the difference between Science and non-science schools of knowledge is that Science is progressive. For example, astrology gets no closer to truth because it cannot find and correct mistakes by comparing itself with reality. “If I have seen further, it is by standing on the shoulders of giants” Newton.

I can’t see how you can think we are no closer to the theory of everything (TOE) than before. Newton did not know about relativity or quantum mechanics. We know more than he did. This is progress to the TOE. I am not sure if we can reach the TOE but it might happen in my lifetime. I am not sure if you are distinguishing between the TOE (which might be indiscoverable or not) and the possibility of science can understand everything (which also may be impossible).

There is much more to be said on this topic, in light of Wittgenstein etc, etc but that is for another time.

(In the same thread on religion, you commented: “…Dawkins and Hitchens have more pressing purposes at hand, surely having demonstrated the unlikelihood of God they must now demonstrate how science is a more reliable answer to all of our uncertainties.”

This is yet another example of turning the discussion away from religion and on to irrelevant issues.)

Anti Citizen One